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M9470084.TXT
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1994-07-02
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Document 0084
DOCN M9470084
TI False-positive rapid plasma reagin tests in human immunodeficiency virus
infection and relationship to anti-cardiolipin antibody and serum
immunoglobulin levels.
DT 9409
AU Rusnak JM; Butzin C; McGlasson D; Blatt SP; Department of Infectious
Diseases, Wilford Hall Medical Center,; Lackland Air Force Base, Texas
78236-5300.
SO J Infect Dis. 1994 Jun;169(6):1356-9. Unique Identifier : AIDSLINE
MED/94253600
AB The incidence of biologic false-positive rapid plasma reagin (RPR) tests
may be increased in human immunodeficiency virus (HIV) infection;
however, injecting drug use has not been excluded as the cause. Review
of 3371 periodic syphilis serology results from 1077 HIV-seropositive
patients in the United States Air Force HIV Natural History Study
between January 1986 and June 1992 revealed a cumulative biologic
false-positive RPR rate of 1%. Most (6/9) were transient low-titer
results associated with a recent acute infectious process.
False-positive RPR tests did not appear to correlate with
anticardiolipin antibody levels or serum IgG or IgA levels, which are
increased in HIV infection. Although not statistically significant,
there was a trend toward higher IgM levels in patients with biologic
false-positive tests. Thus, the incidence of false-positive RPR in an
HIV-infected population with a low risk of injecting drug use is similar
to that in the general population, and the mechanism may correlate with
elevated serum IgM levels.
DE Analysis of Variance Antibodies, Anticardiolipin/*BLOOD Antibodies,
Viral/IMMUNOLOGY False Positive Reactions Female Human HIV
Infections/BLOOD/*DIAGNOSIS/IMMUNOLOGY IgM/BLOOD Male Syphilis
Serodiagnosis JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).